Metode Analisis Paracetamol (Acetaminophen) dalam Darah, Plasma, Dan Serum Manusia

Paracetamol (Acetaminophen) is one of the drugs most often prescribed to patients, ranging from children elderly, as a pain reliever by inhibiting prostaglandin synthesis in central nervous system. has broad therapeutic index with an adult dose 500-1000 mg each time, interval 4-6 hours. The review article aims compare analysis and sample preparation methods used detect paracetamol human blood, plasma, serum. In compiling this article, search method for research journals via internet was Google. results obtained showed that detection blood serum analyzed using Gas Chromatography-Mass Spectrometry (GC-MS) SPE (Solid Phase Extraction) while plasma it several methods, namely Liquid (LC-MS), High-Performance (HPLC-MS), Ultra-High-Performance (UHPLC-MS) protein precipitation liquid-liquid extraction methods. Among four HPLC-MS considered fast, selective, sensitive analyzing